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Pure Medical Rocuronium Bromide , Muscle Relaxants Esmeron CAS 119302-91-9

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Pure Medical Rocuronium Bromide , Muscle Relaxants Esmeron CAS 119302-91-9

Brand Name : Jusheng Brand
Model Number : 119302-91-9
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T, Western Union, MoneyGram, L/C, Bitcion, Paypal
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 119302-91-9
Formula : C32H53BrN2O4
Apparence : White crystalline powder
Purity : 99%
Other name : Rocuronium Bromide; Esmeron; Zemuron,Esmeron
Packing : As Your requirement
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Rocuronium Bromide Non-depolarizing & Muscle Relaxants Raw Material Drug 119302-91-9


Quick detail


Rocuronium bromide
CAS No.:119302-91-9
Synonyms:Esmeron; Zemuron,Esmeron; RocuroniuM BroMide IsoMers; ROCURONIUN BROMIDE; Zemuron; Rocuronium bromide; Pyrrolidinium; Rocuronium Bromide; Eslax; Org-9426;
Formula:C32H53BrN2O4
Exact Mass:608.31900
Molecular Weight:609.67800
PSA:59.00000
LogP:1.30820
Properties
Appearance :white or off-white powder
Melting Point:162-164ºC
Storage Condition:Room temp

Rocuronium Bromide Description


Rocuronium bromide, together with pancuronium, vecuronium, atracurium, and pipecuronium are current commonly used several kinds of clinically non-depolarizing muscle relaxants with Rocuronium bromide having the fastest onset which can provide the ideal conditions of muscle relaxant within 60~90 s.


The binding between non-depolarizing muscle relaxants with motor endplate cholinergic receptor will not change the membrane potential of the motion endplate, but instead hinder the binding between acetylcholine and its receptors, and making muscle relaxation occur.


The muscle relaxant drugs in the event before, unlike depolarizing muscle relaxants, won’t lead to muscle twitching caused by the contraction of muscle fiber bundles before the occurrence of muscle relaxation.
Rocuronium bromide is the derivative of vecuronium, and they have similar role.


Rocuronium Bromide Usage


Uses 1

It is a kind of muscle relaxants and a kind of non-depolarizing neuromuscular blocking agents.

Uses 2It is used as the adjuvant drugs for general anesthesia and conventional intubation of both inpatient and outpatient.
Uses 3It can keep the muscle relaxation during the process of mechanical ventilation and surgery.
Uses 4It is used as a kind of skeletal muscle relaxants (non-depolarizing)
Uses 5Aminosteroid, competitive neuromuscular blocker

Rocuronium Bromide Pharmacological effects


Neuromuscular junction includes motor nerve terminals and motor endplates. Under physiological conditions, when the transmission of nerve impulses to the motor nerve terminals, causing the fusion of vesicle located at motor nerve terminal with the nerve membrane and further discharge of acetylcholine in the vesicular. After leaving the nerve terminal, acetylcholine binds to the acetylcholine receptors located at motor endplate, causing the open of ion channels, and the influx of Na+, resulting in the depolarization of muscle cell, further triggering muscle contraction. According to the difference of muscle relaxants’ nerve impulse disturbances on neuromuscular binding regions, the muscle relaxants are classified into depolarizing muscle relaxants and non-depolarizing muscle relaxants.


Rocuronium bromide is a kind of non-depolarizing neuromuscular blocking agents with a similar chemical structure as vecuronium and pancuronium. Being similar as other non-depolarizing drugs, it competitively binds to the cholinergic receptor located in the motor nerve terminals for antagonism of acetylcholine. This medicine is fast-acting, but acts more slowly than succinylcholine with a big range of safety.


It has a long duration of action and is in dose-dependent manner. Among the non-depolarizing neuromuscular blocking agents, Rocuronium bromide has a most rapid onset with providing an excellent condition for the cannula after intravenous injection for as short as 60 s whose onset time is a bit longer than succinylcholine though, but is two times as fast as vecuronium and tracrium.



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