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CAS 936563-96-1 Ibrutinib

CAS 936563-96-1 Ibrutinib

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Model Number : 936563-96-1
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CAS : 936563-96-1
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Oral Medical Ibrutinib PCI-32765 Anticancer Raw Material Drug CAS 936563-96-1 USAN


Quick detail


Ibrutinib, PCI-32765
CAS No.:936563-96-1
Synonyms:2-​Propen-​1-​one, 1-​[(3R)​-​3-​[4-​amino-​3-​(4-​phenoxyphenyl)​-​1H-​pyrazolo[3,​4-​d]​pyrimidin-​1-​yl]​-​1-​piperidinyl]​-;
Formula:C25H24N6O2
Exact Mass:440.19600
Molecular Weight:440.49700
PSA:99.16000
LogP:4.73640

Ibrutinib Description


Ibrutinib (USAN, also known as PCI-32765 and marketed under the name Imbruvica) is an anticancer drug targeting B-cell malignancies. It is an orally-administered, selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase (BTK).
Ibrutinib was developed by Pharmacyclics, Inc and Johnson & Johnson's Janssen Pharmaceutical division for additional B-cell malignancies including diffuse large B-cell lymphoma and multiple myeloma.
It was approved by the US Food and Drug Administration (FDA) in November 2013 for the treatment of mantle cell lymphoma and in February 2014 for the treatment of chronic lymphocytic leukemia. In January 2015, ibrutinib was approved by the FDA for treatment of Waldenström's macroglobulinemia, a form of non-Hodgkin's lymphoma.


Use in Cancer


Ibrutinib is approved to treat1. Chronic lymphocytic leukemia in patients who have already received other treatment.
2. Mantle cell lymphoma in patients who have already received other treatment.
3. Waldenström macroglobulinemia (a type of non-Hodgkin lymphoma).
4. Ibrutinib is also being studied in the treatment of other types of cancer.

Recommended dose modifications


Toxicity OccurrenceMCL Dose Modification After Recovery Starting Dose = 560 mgCLL and WM Dose Modification After Recovery Starting Dose = 420 mg
FirstRestart at 560 mg dailyRestart at 420 mg daily
SecondRestart at 420 mg dailyRestart at 280 mg daily
ThirdRestart at 280 mg dailyRestart at 140 mg daily
FourthDiscontinue IMBRUVICADiscontinue IMBRUVICA

Oral Administration


Administer once daily at approximately the same time each day

Swallow capsule whole, do not chew, break, open, or crush capsules

Missed dose

  • Take missed dose as soon as possible on the same day and return to normal schedule the following day
  • Do not take extra capsules to make up for the missed dose


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