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Effective Dapagliflozin

Effective Dapagliflozin

Brand Name : Jusheng Brand
Model Number : 461432-26-8
Certification : ISO, 9001, USP
Place of Origin : China
MOQ : 10grams
Price : Discount is possible if your order is big enough
Payment Terms : T/T, Western Union, MoneyGram, L/C, Bitcion, Paypal
Supply Ability : 1000kg/month
Delivery Time : within 2 working days
Packaging Details : 10g, 20g, 50g , 100g, 500g. 1kg, 10kg
CAS : 461432-26-8
Apparence : White Powder
Purity : 99%
Email : linda@hubeijusheng.com
Skype : live: linda_8965
Whatapp : +86 18871490254
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Dapagliflozin CAS 461432-26-8 Effective Antidiabetic Drugs Lowering Blood Glucose


Quick detail


Name:Dapagliflozin
CAS No.:461432-26-8
Formula:C21H25ClO6
Molecular Weight:408.87
Synonyms:BMS 512148;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol;D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-;
Density:1.349 g/cm3
Boiling Point:609.045 °C at 760 mmHg
Flash Point:322.139 °C
Appearance:White Powder

Dapagliflozin Description


Dapagliflozin (ForxigaTM) is a new antidiabetic drug jointly developed by Bristol-Myers Squibb and AstraZeneca, being approved by the European Medicines Agency (EMA) on November 12, 2012. It is also the first approved SGLT2 inhibitor for the treatment of type II diabetes, being an important option in the treatment of diabetes, and is used to improve glycemic control as an adjunct to dietary and exercise for adults with type II diabetes. Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor. On January 8, 2014, the US Food and Drug Administration (FDA) have approved it for being used in the treatment of type II diabetes. Meanwhile, FDA requires the producers to conduct post-marketing research on drug-related risks.


Dapagliflozin Uses


Dapagliflozin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps preventkidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Dapagliflozin works by increasing the removal of sugar by your kidneys.



Mechanism of action


1Dapagliflozin is in a class of drug called SGLT2 inhibitors. These drugs work by targeting and helping to stop sodium-glucose transport proteins from allowing glucose that has been filtered out of the blood by the kidneys to be reabsorbed back into the blood.
2
The SGLT2 proteins are responsible for 90% of the glucose that is reabsorbed into the blood. By inhibiting the SGLT2 proteins, Dapagliflozin allows a significant amount of glucose in the blood to be removed by the kidneys and excreted in the urine.

Who should not take dapagliflozin


Dapagliflozin is not suitable for people who:

  • Have type 1 diabetes
  • Are pregnant or breastfeeding
  • Have low kidney function
  • Are galactose intolerant
  • Have low salt levels in their body
  • Are under the age of 18 or over the age 75
  • People on a course of Actos (pioglitazone) or loop diuretics should also avoid taking Forxiga.

Dapagliflozin Side effects


Side effects of Dapagliflozin may include:

  1. Hypoglycemia –if taken with sulphonylureas or insulin
  2. Thrush
  3. Urinary tract infections
  4. Increased need to visit the toilet (polyuria)
  5. Pain when urinating
  6. Changes in levels of blood fats
  7. Lowering of blood pressure

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