Dapagliflozin CAS 461432-26-8 Effective Antidiabetic Drugs Lowering
|Boiling Point:||609.045 °C at 760 mmHg|
|Flash Point:||322.139 °C|
Dapagliflozin (ForxigaTM) is a new antidiabetic drug jointly
developed by Bristol-Myers Squibb and AstraZeneca, being approved
by the European Medicines Agency (EMA) on November 12, 2012. It is
also the first approved SGLT2 inhibitor for the treatment of type
II diabetes, being an important option in the treatment of
diabetes, and is used to improve glycemic control as an adjunct to
dietary and exercise for adults with type II diabetes.
Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor. On
January 8, 2014, the US Food and Drug Administration (FDA) have
approved it for being used in the treatment of type II diabetes.
Meanwhile, FDA requires the producers to conduct post-marketing
research on drug-related risks.
Dapagliflozin is used with a proper diet and exercise program to
control high blood sugar in people with type 2 diabetes.
Controlling high blood sugar helps preventkidney damage, blindness,
nerve problems, loss of limbs, and sexual function problems. Proper
control of diabetes may also lessen your risk of a heart attack or
stroke. Dapagliflozin works by increasing the removal of sugar by
Mechanism of action
|1||Dapagliflozin is in a class of drug called SGLT2 inhibitors. These
drugs work by targeting and helping to stop sodium-glucose
transport proteins from allowing glucose that has been filtered out
of the blood by the kidneys to be reabsorbed back into the blood.|
The SGLT2 proteins are responsible for 90% of the glucose that is
reabsorbed into the blood. By inhibiting the SGLT2 proteins,
Dapagliflozin allows a significant amount of glucose in the blood
to be removed by the kidneys and excreted in the urine.
Who should not take dapagliflozin
Dapagliflozin is not suitable for people who:
- Have type 1 diabetes
- Are pregnant or breastfeeding
- Have low kidney function
- Are galactose intolerant
- Have low salt levels in their body
- Are under the age of 18 or over the age 75
- People on a course of Actos (pioglitazone) or loop diuretics should
also avoid taking Forxiga.
Dapagliflozin Side effects
Side effects of Dapagliflozin may include:
- Hypoglycemia –if taken with sulphonylureas or insulin
- Urinary tract infections
- Increased need to visit the toilet (polyuria)
- Pain when urinating
- Changes in levels of blood fats
- Lowering of blood pressure